QTc Dispersion in Cardiac Autonomic Neuropathy and Its Correlation With Diastolic Dysfunction In Type 2 Diabetes: The Basis for Non Ischemic Diabetic Cardiomyopathy

INTRODUCTION: Diabetic cardiac autonomic neuropathy is aserious complication with poor prognosis results in silent ischemia and left ventricle dysfunction. Increased QT dispersion is used as a marker of diabetic autonomic neuropathy .Sympathetic overactivity stimulates RAAS which has direct noxious effects on cardiomyocytes. AIM OF THE STUDY: The primary aim of this study is to observe the utility of prolongation of corrected (QTc) interval in the ECG to diagnose CAN in patients with diabetes mellitus and to study the prevalence of diastolic dysfunction –the basis for non ischemic cardiomyopathy?. Secondarily to study the prevalence and risk factors for cardiac autonomic neuropathy. MATERIALS AND METHODS: An observational study was conducted in our hospital among 100 type 2 diabetic patients of more than 5 yrs duration without any complications and 100 age and sex matched healthy individuals as controls .All undergone cardiac autonomic function tests using CAN analyser and were graded as normal mild and severe. QTd were calculated using bazets formula in 12 lead ecg. All were subjected to echo. Left ventricle diastolic dysfunction were graded as normal grade 1/2/3. Statistical analysis were done using SPSS software. RESULTS: QT d and CAN association are statistically significant. There is association between QTD and LVDD.Prevalence of CAN and LVDD is high. Age, duration obesity, duration of diabetes ,glycemic control all influences CAN. CONCLUSION: Prevalence of cardiac autonomic neuropathy and left ventricle diastolic dysfunction is high which produces serious morbidity and mortality .With using simple ecg and echo testing in type 2 diabetic patients of longer duration we can identify high risk group for sudden cardiac death in early stag

Develop a Hybrid Classification using an Ensemble Model for Phishing Website Detection

Solutions to threats posed by technical and social vulnerabilities must be found to secure the web interface. Social engineering attacks frequently use phishing as one of their vectors. The importance is promptly detecting phishing attacks has increased. The classifier model was constructed using publicly accessible data from trustworthy and phishing websites. A variety of methods were used to extract relevant features to build the model. Before a user experiences any harm, Machine Learning algorithms can reliably identify phishing attacks. To identify phishing attacks on the website, this study presents a novel ensemble model. In this paper, the Artificial Neural Network (ANN) and the Random Forest Classifier (RFC) are used in an ensemble method along with the Support Vector Machine (SVM). Compared to previous studies, this ensemble method more accurately and efficiently detects website phishing attacks. According to experimental findings, the proposed system detects phishing attacks 97.3% of the time

Effectiveness of back massage on fatigue and anxiety among patients receiving chemotherapy in oncology ward at Government Rajaji Hospital, Madurai

Title: Effectiveness of back massage on fatigue and anxiety among patients receiving chemotherapy in oncology ward at Government Rajaji Hospital, Madurai-20. Objectives: Assess the pretest level of fatigue and anxiety among the patient receiving chemotherapy. Assess the effectiveness of back massage on fatigue and anxiety among patient receiving chemotherapy. Associate the level of fatigue and anxiety among patients receiving chemotherapy with selected demographic and clinical variables. Assess the co-relation between chemotherapy related fatigue and anxiety. Hypotheses: There is a significant difference between the pretest and post test level of fatigue and anxiety among patients receiving chemotherapy. There is a significant association in the level of fatigue and anxiety among patients receiving chemotherapy with the selected demographic and clinical variables. There is a significant correlation between fatigue and anxiety among patients receiving chemotherapy. Conceptual framework: Martha Rogers’s science of unitary human being model. Methodology: A Quantitative approach -quasi experimental-Non equivalent control group design was used, the study was conducted at oncology ward in Government Rajaji Hospital, Madurai-20.sample size was 60, 30 in each group, assigned by consecutive sampling. Pre test was done using spielberger-state anxiety inventory and Brief Fatigue Inventory. Back massage (effleurage, petrissage, tapotment, and vibration) for 15 minutes for 3 consecutive days was given to the subjects in the experimental group. On third day post test was done using same tools. Findings: The mean pre-test fatigue and anxiety score reduced from 4.15 to 2.41, 41.1 to30.7 in the post test respectively. Conclusion: The findings proved that the Back massage can be used in reducing the chemotherapy related fatigue and anxiety

A study to assess the effectiveness of Tactile/Kinesthetic stimulation Vs Olive Oil massage on selected biophysiological parameters among low birth weight babies in selected hospital, Perambalur District

BACKGROUND: Oil massage therapy and tactile / kinesthetic, promotes the weight gain, increases appetite, improve in sucking behavior, thermoregulation, positive effects on neurobehavioral pattern, enhance mother to child bonding and induce sleep, which helps the preterm infants and low birth weight babies to improve health status as like term infants and decreases the mortality, morbidity rate. STATEMENT OF THE PROBLEM: A study to assess the effectiveness of tactile/kinesthetic stimulation Vs olive oil massage on selected biophysiological parameters among low birth weight babies in selected hospital, Perambalur District. OBJECTIVES: 1. Assess the level of biophysiological parameters before and after tactile/kinesthetic stimulation Vs olive oil massage among low birth weight babies in experimental group I and II. 2. Assess the effectiveness of tactile/kinesthetic stimulation Vs olive oil massage on selected biophysiological parameters among low birth weight babies in experimental group I and II. (3) Compare the effectiveness of tactile/kinesthetic stimulation Vs olive oil massage on selected biophysiological parameters among low birth weight babies in experimental group I and II. (4) Find out the association between the selected demographic variable and post test scores of tactile/kinesthetic stimulation and olive oil massage on selected biophysiological parameters among low birth weight babies in experimental group I and II. Research Design: Factorial Research Design. Setting: The present study was conducted in Ramasamy Hospital, Perambalur district. Participants: The total 30 babies out of which 15 babies from experimental group I and 15 babies from experimental group II. METHOD: Prior to the collection of the data, permission was obtained from the managing director, Ramasamy hospital, Perambalur District. The investigator collected the data from the low birth weight newborn at Ramasamy hospital, Perambalur District. Demographic variables were collected. The bio physiological parameters were monitored. Throughout the procedure aseptic measures were taken. Immediately after pre test the participants randomly assigned to 1 of 2 groups. The participants received allocated treatment as flows. It refers to 10 minutes of tactile and kinaesthetic stimulations which includes 3 minutes of tactile stimulation, 4 minutes of kinaesthetic stimulation followed by 3 minutes of tactile stimulation; thrice a day for 5 days was provided. Olive oil which is used to massage the body in order to improve skin texture and increase thermoregulation in a therapeutic maneuver of manipulating the soft tissues firm strokes with palms of the hands from head to foot for 5 minutes, thrice a day for 5 days. The bio physiological parameters were monitored. Throughout the procedure aseptic measures were taken by the researcher. RESULT: In experimental group I: The chi square value of gestational age was 4.86 (p < 0.05). •The chi square value of birth weight was 5.13 (p < 0.05). •The chi square value of gender was 1.35 (p < 0.05). •The chi square value of APGAR score was 1.64 (p < 0.05). •The chi square value of birth order was 0.33 (p < 0.05). •The chi square value of history of antenatal complications of 0.94 (p < 0.05). •The chi square value of history of neonatal complications 1.31 (p < 0.05). It reveals that there were no significant association found between the post test scores of Experimental group I and demographic variables. In experimental group II: The chi square value of gestational age was 2.73 (p < 0.05). •The chi square value of birth weight was 4.58 (p < 0.05). •The chi square value of gender was 1.05 (p < 0.05). •The chi square value of APGAR score was 1.45 (p < 0.05). •The chi square value of birth order was 1.38 (p < 0.05). •The chi square value of history of antenatal complications of 1.81 (p < 0.05). •The chi square value of history of neonatal complications 0.58 (p < 0.05). It reveals that there were no significant association found between the post test scores of Experimental group II and demographic variables. CONCLUSION: From the findings of the study it can be concluded that, there were significant effectiveness of tactile/kinesthetic stimulation and olive oil massage on bio physiological parameters among low birth weight newborn. There were no significant difference in the effectiveness of tactile/kinesthetic stimulation and olive oil massage on bio physiological parameters among low birth weight newborn. There were no significant association between post test scores of bio physiological parameters and their selected demographic variables

catena-Poly[ammonium (cadmium-tri-μ-thio­cyanato-κ4 S:N;κ2 N:S)–1,4,10,13,16-hexa­oxa­cyclo­octa­decane (1/1)]

In the title compound, {(NH4)[Cd(NCS)3]·C12H24O6}n, the Cd2+ ion, the ammonium cation, one of the SCN− ligands and the macrocycle are located on mirror planes. The thiocyanate anions act as bridging ligands between the CdII ions, leading to a polymeric chain arrangement extending along [001] around a twofold screw axis. The ammonium ions are contained within the bowl of the macrocycle via extensive N—H⋯O hydrogen bonding

In vitro anticancer activity of Sargassum sp. polysaccharides against MCF-7 cell lines

1267-1273Seaweed polysaccharides are compounds with promising chemopreventive and chemotherapeutic activities. In this study, polysaccharides isolated from Sargassum seaweeds were tested for their efficiency in cancer therapy. Polysaccharides were isolated, purified, and characterized using nuclear magnetic resonance (NMR); and Fourier transform infrared (FT-IR) spectroscopic and matrix-assisted laser desorption ionization mass spectrometric (MALDI-MS). It was found that the polysaccharides from Sargassum sp. branches are sulfated galactose–fucose disaccharides and sulfated galactose monosaccharides attached to the main chain through (1–4) linkages. Further, the polysaccharides were tested for cytotoxicity and anticancer activity against human breast adenocarcinoma cell line (MCF-7) using the Annexin-V/propidium iodide (PI) staining method

Analysis of Higher Order Multipoles of the 952.6 Mhz RF-Dipole Crabbing Cavity for the Jefferson Lab Electron Ion Collider

The crabbing system is a key feature in the Jefferson Lab Electron-Ion Collider (JLEIC) required to increase the luminosity of the colliding bunches. A local crabbing system will be installed with superconducting rf-dipole crabbing cavities operating at 952.6 MHz. The field non-uniformity across the beam aperture in the crabbing cavities produces higher order multipole components, similar to that which are present in magnets. Knowledge of higher order mode multipole field effects is important for accurate beam dynamics study for the crabbing system. In this paper, we quantify the multipole components and analyse their effects on the beam dynamics

Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Ginger and Cinnamon Essential Oil and Extracts as Regulated by Their Isolation Procedures

Our research compared the chemical make-up of wild Ginger and cinnamon, including their essential oils (EOs), total phenol, and total flavonoid, for their antioxidant and antibacterial effects in vitro. The mineral (nutritional and poisonous) components of the plant were also identified in this investigation. Hydro distillation (HD), steam distillation (SD), and microwave-assisted distillation (MAD) were used to extract the EOs, and gas chromatography with flame ionization detection (GC-FID) and mass spectrometry detection (GC-MS) were used to examine them. 2,2-diphenyl-1-picrylhydrazyl (DPPH) was used to evaluate the EOs' antioxidant properties. The essential oil was analyzed, and twenty-six components were found to make up 97.73% of the oil with a yield of 0.202%. The primary components were pulegone (74.81%), menthone (13.01%) and piperitone (3.82%). Neutron activation analysis (INAA) and inductively coupled plasma optical emission spectrometry (ICP-OES) were used to detect twenty-one elements, including macro- and micro-elements (Ba, Br, Ca, Cl, Co, Cr, Cs, Eu, Fe, K, Mg, Mn, Mo, Na, Rb, Sb, Sc, Sr, Th, U, and Zn), with the mineral element concentration being very close to the FAO recommendation

A Wearable Arm and Wrist Rehabilitation Exercise Device Equipped with Monitoring System for Post Stroke Rehabilitation

An analysis of rehabilitation activity for paralyzed patient. Monitoring rehabilitation activity for post-stroke patients have increasingly common in hospitals and rehabilitation center worldwide. To develop home based and low cost device for post-stroke patients activity monitoring is challenging in rehabilitation engineering. Many technological devices have been developed like a Wearable Arm and Wrist Rehabilitation Exercise device equipped with monitoring system for post stroke rehabilitation were designed for and proposed.  In this article, we identify several functional activities of arm and wrist motoring defect is achieved by the exoskeleton system. This system is controlled by the Arduino UNO Microcontroller and the LCD is acting as monitoring unit. This allows investigating patterns of patient’s arm and wrist monitoring functional activity. These studies investigated the activation patterns in different experimental conditions such as water bottle take off, wrist stretching and grasp force. Furthermore, findings attained from this project may enable us to contribute towards the development of new arm rehabilitation monitoring device which can benefit human lives

Crab Crossing Schemes and Studies for Electron Ion Collider

This report shows our progress in crab crossing consideration for future electron-ion collider envisioned at JLab. In this design phase, we are evaluating two crabbing schemes viz., the deflecting and dispersive. The mathematical formulations and lattice design for these schemes are discussed in this paper. Numerical simulations involving particle tracking through a realistic deflecting RF cavity and optics illustrate the desired crab tilt of 25 mrad for 1.35 MV. Evolution of beam propagation are shown which provides the physical insight of the crabbing phenomenon